Immunogenicity and Safety of Influenza Vaccine in Inflammatory Bowel Disease Patients Treated or not with Immunomodulators and/or Biologics: A Two-year Prospective Study.
Identifieur interne : 000077 ( France/Analysis ); précédent : 000076; suivant : 000078Immunogenicity and Safety of Influenza Vaccine in Inflammatory Bowel Disease Patients Treated or not with Immunomodulators and/or Biologics: A Two-year Prospective Study.
Auteurs : Odile Launay [France] ; Vered Abitbol [France] ; Anne Krivine ; Lilia Ben Slama [France] ; Arnaud Bourreille [France] ; Jean Louis Dupas [France] ; Xavier Hébuterne [France] ; Guillaume Savoye [France] ; Dominique Deplanque [France] ; Yoram Bouhnik [France] ; Anne Laure Pelletier [France] ; Florence Galtier [France] ; David Laharie [France] ; Maria Nachury ; Frank Zerbib [France] ; Mathieu Allez [France] ; Gilles Bommelaer [France] ; Bernard Duclos [France] ; Frederic Lucht [France] ; Marie-Lise Gougeon [France] ; Eric Tartour [France] ; Flore Rozenberg [France] ; Thomas Hanslik [France] ; Laurent Beaugerie [France] ; Fabrice Carrat [France]Source :
- Journal of Crohn's & Colitis [ 1876-4479 ] ; 2015-11-30.
Abstract
Data on the efficacy and safety of seasonal influenza vaccines in patients with inflammatory bowel disease (IBD) remain scarce. The aim of the study was to evaluate the impact of immunosuppressive (IS) therapeutics on serological response to 2-year influenza vaccination in IBD adults. A multicentre prospective study performed in 255 IBD adults (18-64 years) receiving the trivalent influenza vaccine in the years 2009-2010 and 2010-2011. Haemagglutination inhibition (HI) titres were assessed before and 3 weeks and 6 months after vaccination. At inclusion, 31 patients were receiving no IS treatment (Group A), 77 were receiving IS treatment without anti-TNF (Group B) and 117 were receiving anti-tumour necrosis factor (TNF) treatment with or without IS treatment (Group C). Three weeks after the first vaccination, rates of seroprotection were 77, 75 and 66% for strain A/H1N12007 (p = 0.35), 77, 68 and 52% for strain A/H3N2 (p = 0.014) and 97, 96 and 95% for strain B (p = 0.99) in Groups A, B and C, respectively. Seroconversion rates for A/H1N12007 (67, 64 and 54%; p = 0.28), A/H3N2 (63, 50 and 41%; p = 0.074) and strain B (63, 76 and 60%; p = 0.078) were not significantly different among treatment groups. At 6 months after vaccination, seroprotection rates were lower in Group C compared with Groups A and B. Comparable results were observed for the second year of vaccination. No impact on Harvey-Bradshaw and Mayo scores was detected. Influenza vaccine yielded high seroprotection rates in IBD patients. Persistence of seroprotection was lower in patients with anti-TNF treatment. ClinicalTrials.gov, number NCT01022749.
Url:
DOI: 10.1093/ecco-jcc/jjv152
Affiliations:
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Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID"> <orgName>CHU Tenon [APHP]</orgName> <desc> <address> <addrLine>4 Rue de la Chine, 75020 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Bourreille, Arnaud" sort="Bourreille, Arnaud" uniqKey="Bourreille A" first="Arnaud" last="Bourreille">Arnaud Bourreille</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-46224" status="VALID"> <orgName>Neuropathies du système nerveux entérique et pathologies digestives; implication des cellules gliales entériques</orgName> <desc> <address> <addrLine>1 Place Alexis Ricordeau, 44093 Nantes</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93263" type="direct"></relation> <relation name="U913" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93263" type="direct"><org type="institution" xml:id="struct-93263" status="VALID"> <idno type="IdRef">026403447</idno> <orgName>Université de Nantes</orgName> <orgName type="acronym">UN</orgName> <desc> <address> <addrLine>1, quai de Tourville - 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CS 14032 - 14032 Caen Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.normandie-univ.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Deplanque, Dominique" sort="Deplanque, Dominique" uniqKey="Deplanque D" first="Dominique" last="Deplanque">Dominique Deplanque</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2617" status="OLD"> <orgName>CIC CHU ( Lille)/inserm</orgName> <desc> <address> <addrLine>Hopital Cardiologique LILLE , Bd du Pr Jules Leclercq 59037 LILLE CEDEX</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="CIC9301" active="#struct-303623" type="direct"></relation> <relation active="#struct-361611" type="direct"></relation> </listRelation> <tutelles><tutelle name="CIC9301" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD"> <idno type="IdRef">026404389</idno> <idno type="ISNI">0000000120977060</idno> <orgName>Université de Lille, Droit et Santé</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>42 rue Paul Duez 59000 Lille</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-lille2.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Bouhnik, Yoram" sort="Bouhnik, Yoram" uniqKey="Bouhnik Y" first="Yoram" last="Bouhnik">Yoram Bouhnik</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-175338" status="INCOMING"> <orgName>Pole des maladies de l'appareil digestif, gastroentérologie et assistance nutritive</orgName> <desc> <address> <addrLine>92100;Clichy</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-344345" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-344345" type="direct"><org type="institution" xml:id="struct-344345" status="INCOMING"> <orgName>AP-HP Hôpital Beaujon</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pelletier, Anne Laure" sort="Pelletier, Anne Laure" uniqKey="Pelletier A" first="Anne Laure" last="Pelletier">Anne Laure Pelletier</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-26728" status="INCOMING"> <orgName>Hôpital Bichat - Claude Bernard</orgName> <desc> <address> <addrLine>46, rue Henri-Huchard 75018 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Galtier, Florence" sort="Galtier, Florence" uniqKey="Galtier F" first="Florence" last="Galtier">Florence Galtier</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-303483" status="VALID"> <orgName>CHU Saint-Eloi</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Laharie, David" sort="Laharie, David" uniqKey="Laharie D" first="David" last="Laharie">David Laharie</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-24340" status="VALID"> <orgName>Service d'Hépato-Gastro-Entérologie</orgName> <desc> <address> <addrLine>Bordeaux</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300122" type="direct"></relation> <relation active="#struct-300817" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300122" type="direct"><org type="institution" xml:id="struct-300122" status="VALID"> <orgName>CHU Bordeaux [Bordeaux]</orgName> <desc> <address> <addrLine>place Amélie Raba Léon33076 BORDEAUX CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-bordeaux.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300817" type="direct"><org type="institution" xml:id="struct-300817" status="VALID"> <orgName>Hôpital Saint-André</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Nachury, Maria" sort="Nachury, Maria" uniqKey="Nachury M" first="Maria" last="Nachury">Maria Nachury</name></author><author><name sortKey="Zerbib, Frank" sort="Zerbib, Frank" uniqKey="Zerbib F" first="Frank" last="Zerbib">Frank Zerbib</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-24340" status="VALID"> <orgName>Service d'Hépato-Gastro-Entérologie</orgName> <desc> <address> <addrLine>Bordeaux</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300122" type="direct"></relation> <relation active="#struct-300817" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300122" type="direct"><org type="institution" xml:id="struct-300122" status="VALID"> <orgName>CHU Bordeaux [Bordeaux]</orgName> <desc> <address> <addrLine>place Amélie Raba Léon33076 BORDEAUX CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-bordeaux.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300817" type="direct"><org type="institution" xml:id="struct-300817" status="VALID"> <orgName>Hôpital Saint-André</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Allez, Mathieu" sort="Allez, Mathieu" uniqKey="Allez M" first="Mathieu" last="Allez">Mathieu Allez</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-85046" status="OLD"> <orgName>Hôpital Saint-Louis</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>1, avenue Claude-Vellefaux 75475 PARIS Cedex 10</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300301" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Bommelaer, Gilles" sort="Bommelaer, Gilles" uniqKey="Bommelaer G" first="Gilles" last="Bommelaer">Gilles Bommelaer</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Duclos, Bernard" sort="Duclos, Bernard" uniqKey="Duclos B" first="Bernard" last="Duclos">Bernard Duclos</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-434774" status="INCOMING"> <orgName>Departement de Gastroentérologie</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-357391" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-357391" type="direct"><org type="institution" xml:id="struct-357391" status="VALID"> <orgName>Hôpital de Hautepierre [Strasbourg]</orgName> <desc> <address> <addrLine>Avenue Molière67200 Strasbourg</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chru-strasbourg.fr/Hopital-de-Hautepierre</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Lucht, Frederic" sort="Lucht, Frederic" uniqKey="Lucht F" first="Frederic" last="Lucht">Frederic Lucht</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3137" status="VALID"> <orgName>Groupe Immunité des Muqueuses et Agents Pathogènes</orgName> <orgName type="acronym">GIMAP</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://gimap.univ-st-etienne.fr</ref> </desc> <listRelation> <relation name="EA3064" active="#struct-300284" type="direct"></relation> </listRelation> <tutelles><tutelle name="EA3064" active="#struct-300284" type="direct"><org type="institution" xml:id="struct-300284" status="VALID"> <orgName>Université Jean Monnet [Saint-Étienne]</orgName> <orgName type="acronym">UJM</orgName> <desc> <address> <addrLine>10 rue Tréfilerie - 42100 Saint-Étienne</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-st-etienne.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Gougeon, Marie Lise" sort="Gougeon, Marie Lise" uniqKey="Gougeon M" first="Marie-Lise" last="Gougeon">Marie-Lise Gougeon</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-123746" status="VALID"> <orgName>Immunité Anti-virale, Biothérapie et Vaccins</orgName> <orgName type="acronym">IABV</orgName> <desc> <address> <addrLine>Département Infection et Epidémiologie, 25 rue du Dr Roux 75725 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/en/team/antiviral-immunity-biotherapy-and-vaccines/</ref> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-81503" status="OLD"> <idno type="IdRef">166439185</idno> <idno type="ISNI">0000 0004 0495 1460 </idno> <idno type="RNSR">201019165T</idno> <orgName>Paris-Centre de Recherche Cardiovasculaire</orgName> <orgName type="acronym">PARCC - UMR-S U970</orgName> <date type="start">2009-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>56 rue Leblanc75015 PARISFRANCE</addrLine> <country key="FR"></country> </address> <ref type="url">http://parcc.inserm.fr/</ref> </desc> <listRelation> <relation name="UMR_S 970" active="#struct-301664" type="direct"></relation> <relation name="U970" active="#struct-300119" type="direct"></relation> <relation active="#struct-300068" type="indirect"></relation> <relation active="#struct-353414" type="indirect"></relation> <relation name="U970" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_S 970" active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD"> <idno type="IdRef">026404788</idno> <idno type="ISNI">0000 0001 2188 0914 </idno> <orgName>Université Paris Descartes - Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </org></tutelle><tutelle name="U970" active="#struct-300119" type="direct"><org type="institution" xml:id="struct-300119" status="VALID"> <orgName>Hôpital Européen Georges Pompidou [APHP]</orgName> <orgName type="acronym">HEGP</orgName> <desc> <address> <addrLine>20, rue Leblanc, 75015 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://hopital-georgespompidou.aphp.fr/</ref> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353414" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-300068" type="indirect"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353414" type="indirect"><org type="regroupinstitution" xml:id="struct-353414" status="VALID"> <orgName>Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest</orgName> <orgName type="acronym">HUPO</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://hopitaux-parisouest.aphp.fr/</ref> </desc> </org></tutelle><tutelle name="U970" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-107953" status="INCOMING"> <orgName>Laboratoire de Virologie</orgName> <desc> <address> <addrLine>Department of Virology, Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300872" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300872" type="direct"><org type="institution" xml:id="struct-300872" status="VALID"> <orgName>Hôpital Saint-Vincent de Paul</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Hanslik, Thomas" sort="Hanslik, Thomas" uniqKey="Hanslik T" first="Thomas" last="Hanslik">Thomas Hanslik</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-81173" status="VALID"> <idno type="IdRef">03082057X</idno> <idno type="ISNI">0000 0001 2323 0229 </idno> <orgName>Université de Versailles Saint-Quentin-en-Yvelines</orgName> <orgName type="acronym">UVSQ</orgName> <date type="start">1991-07-22</date> <desc> <address> <addrLine>55 avenue de Paris - 78035 Versailles cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.uvsq.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Beaugerie, Laurent" sort="Beaugerie, Laurent" uniqKey="Beaugerie L" first="Laurent" last="Beaugerie">Laurent Beaugerie</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Carrat, Fabrice" sort="Carrat, Fabrice" uniqKey="Carrat F" first="Fabrice" last="Carrat">Fabrice Carrat</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-245392" status="INCOMING"> <orgName>Epidémiologie, Systèmes dínformation et modélisation</orgName> <orgName type="acronym">ESIM</orgName> <desc> <address> <addrLine>Faculté de Médecine Pierre et Marie Curie, site Saint-Antoine, 27 rue Chaligny, 75571. Paris Cedex 12</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="UMRS 707" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle name="UMRS 707" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1093/ecco-jcc/jjv152</idno><series><title level="j">Journal of Crohn's & Colitis</title><idno type="ISSN">1876-4479</idno><imprint><date type="datePub">2015-11-30</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Data on the efficacy and safety of seasonal influenza vaccines in patients with inflammatory bowel disease (IBD) remain scarce. The aim of the study was to evaluate the impact of immunosuppressive (IS) therapeutics on serological response to 2-year influenza vaccination in IBD adults. A multicentre prospective study performed in 255 IBD adults (18-64 years) receiving the trivalent influenza vaccine in the years 2009-2010 and 2010-2011. Haemagglutination inhibition (HI) titres were assessed before and 3 weeks and 6 months after vaccination. At inclusion, 31 patients were receiving no IS treatment (Group A), 77 were receiving IS treatment without anti-TNF (Group B) and 117 were receiving anti-tumour necrosis factor (TNF) treatment with or without IS treatment (Group C). Three weeks after the first vaccination, rates of seroprotection were 77, 75 and 66% for strain A/H1N12007 (p = 0.35), 77, 68 and 52% for strain A/H3N2 (p = 0.014) and 97, 96 and 95% for strain B (p = 0.99) in Groups A, B and C, respectively. Seroconversion rates for A/H1N12007 (67, 64 and 54%; p = 0.28), A/H3N2 (63, 50 and 41%; p = 0.074) and strain B (63, 76 and 60%; p = 0.078) were not significantly different among treatment groups. At 6 months after vaccination, seroprotection rates were lower in Group C compared with Groups A and B. Comparable results were observed for the second year of vaccination. No impact on Harvey-Bradshaw and Mayo scores was detected. Influenza vaccine yielded high seroprotection rates in IBD patients. Persistence of seroprotection was lower in patients with anti-TNF treatment. ClinicalTrials.gov, number NCT01022749. </p> </div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement><orgName><li>Université de Nantes</li></orgName></list><tree><noCountry><name sortKey="Krivine, Anne" sort="Krivine, Anne" uniqKey="Krivine A" first="Anne" last="Krivine">Anne Krivine</name><name sortKey="Nachury, Maria" sort="Nachury, Maria" uniqKey="Nachury M" first="Maria" last="Nachury">Maria Nachury</name></noCountry><country name="France"><noRegion><name sortKey="Launay, Odile" sort="Launay, Odile" uniqKey="Launay O" first="Odile" last="Launay">Odile Launay</name></noRegion><name sortKey="Abitbol, Vered" sort="Abitbol, Vered" uniqKey="Abitbol V" first="Vered" last="Abitbol">Vered Abitbol</name><name sortKey="Allez, Mathieu" sort="Allez, Mathieu" uniqKey="Allez M" first="Mathieu" last="Allez">Mathieu Allez</name><name sortKey="Beaugerie, Laurent" sort="Beaugerie, Laurent" uniqKey="Beaugerie L" first="Laurent" last="Beaugerie">Laurent Beaugerie</name><name sortKey="Bommelaer, Gilles" sort="Bommelaer, Gilles" uniqKey="Bommelaer G" first="Gilles" last="Bommelaer">Gilles Bommelaer</name><name sortKey="Bouhnik, Yoram" sort="Bouhnik, Yoram" uniqKey="Bouhnik Y" first="Yoram" last="Bouhnik">Yoram Bouhnik</name><name sortKey="Bourreille, Arnaud" sort="Bourreille, Arnaud" uniqKey="Bourreille A" first="Arnaud" last="Bourreille">Arnaud Bourreille</name><name sortKey="Carrat, Fabrice" sort="Carrat, Fabrice" uniqKey="Carrat F" first="Fabrice" last="Carrat">Fabrice Carrat</name><name sortKey="Deplanque, Dominique" sort="Deplanque, Dominique" uniqKey="Deplanque D" first="Dominique" last="Deplanque">Dominique Deplanque</name><name sortKey="Duclos, Bernard" sort="Duclos, Bernard" uniqKey="Duclos B" first="Bernard" last="Duclos">Bernard Duclos</name><name sortKey="Dupas, Jean Louis" sort="Dupas, Jean Louis" uniqKey="Dupas J" first="Jean Louis" last="Dupas">Jean Louis Dupas</name><name sortKey="Galtier, Florence" sort="Galtier, Florence" uniqKey="Galtier F" first="Florence" last="Galtier">Florence Galtier</name><name sortKey="Gougeon, Marie Lise" sort="Gougeon, Marie Lise" uniqKey="Gougeon M" first="Marie-Lise" last="Gougeon">Marie-Lise Gougeon</name><name sortKey="Hanslik, Thomas" sort="Hanslik, Thomas" uniqKey="Hanslik T" first="Thomas" last="Hanslik">Thomas Hanslik</name><name sortKey="Hebuterne, Xavier" sort="Hebuterne, Xavier" uniqKey="Hebuterne X" first="Xavier" last="Hébuterne">Xavier Hébuterne</name><name sortKey="Laharie, David" sort="Laharie, David" uniqKey="Laharie D" first="David" last="Laharie">David Laharie</name><name sortKey="Lucht, Frederic" sort="Lucht, Frederic" uniqKey="Lucht F" first="Frederic" last="Lucht">Frederic Lucht</name><name sortKey="Pelletier, Anne Laure" sort="Pelletier, Anne Laure" uniqKey="Pelletier A" first="Anne Laure" last="Pelletier">Anne Laure Pelletier</name><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><name sortKey="Savoye, Guillaume" sort="Savoye, Guillaume" uniqKey="Savoye G" first="Guillaume" last="Savoye">Guillaume Savoye</name><name sortKey="Slama, Lilia Ben" sort="Slama, Lilia Ben" uniqKey="Slama L" first="Lilia Ben" last="Slama">Lilia Ben Slama</name><name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name><name sortKey="Zerbib, Frank" sort="Zerbib, Frank" uniqKey="Zerbib F" first="Frank" last="Zerbib">Frank Zerbib</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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